Structure of PDB 3oui Chain A

Receptor sequence
>3ouiA (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
PALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDG
QDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKA
MVACYPGNGTGYVRHVDNPRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQ
FADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFD
3D structure
PDB3oui Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H313 D315 H374 H115 D117 H172
BS02 42Z A R252 M299 Y310 H313 D315 Y329 H374 V376 R383 W389 R54 M101 Y112 H115 D117 Y127 H172 V174 R181 W187 PDBbind-CN: -logKd/Ki=4.90,IC50=12.6uM
BindingDB: IC50=12589.25nM
BS03 42Z A N203 I280 C283 K286 S289 Y290 N15 I82 C85 K88 S91 Y92 PDBbind-CN: -logKd/Ki=4.90,IC50=12.6uM
BindingDB: IC50=12589.25nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:3oui, PDBe:3oui, PDBj:3oui
PDBsum3oui
PubMed24900242
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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