Structure of PDB 3otx Chain A

Receptor sequence
>3otxA (length=338) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
APLRVYVQCNPLLDVSAHVSDEFLVKYGLERGTAILLSERQKGIFDDIEK
MPNVRYVPGGSGLNVARVAQWMQQAYKGKFVTYVGCIADDRYGKVLKEAA
EHEGIVMAVEHTTKAGSGACAVCITGKERTLVADLGAANHLSSEHMRSPA
VVRAMDESRIFYFSGFTLTVDVNHVLQACRKAREVDGLFMINLSAPFIMQ
FFSAQLGEVLPYTDIIVANRHEAKEFANMMKWDTDCVEEIARRAVSEVPY
TGTKGRVVVFTRDIESTVLATKDGVETVPVPQLDQDKVIDMNGAGDAFMG
GFLSAYAVGKDLRRCCETGHYTAQEVIQRDPEKPSFSP
3D structure
PDB3otx Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R132 D299
Catalytic site (residue number reindexed from 1) R129 D296
Enzyme Commision number 2.7.1.20: adenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AP5 A N13 L15 D17 G63 S64 N67 C123 R132 A136 F169 N222 T264 D266 I267 V283 Q288 G296 A297 G298 D299 H323 A326 Q327 I330 N10 L12 D14 G60 S61 N64 C120 R129 A133 F166 N219 T261 D263 I264 V280 Q285 G293 A294 G295 D296 H320 A323 Q324 I327 MOAD: ic50=29.4uM
PDBbind-CN: -logKd/Ki=4.53,IC50=29.4uM
Gene Ontology
Molecular Function
GO:0004001 adenosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006166 purine ribonucleoside salvage
GO:0009152 purine ribonucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0044209 AMP salvage
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0020015 glycosome
GO:0097014 ciliary plasm

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Biological Process
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Cellular Component
External links
PDB RCSB:3otx, PDBe:3otx, PDBj:3otx
PDBsum3otx
PubMed21629723
UniProtQ584S0

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