Structure of PDB 3otk Chain A

Receptor sequence
>3otkA (length=369) Species: 10090 (Mus musculus) [Search protein sequence]
NVNCTKILQGDPEEIQKVKLEILTVQFKKRPRWTPHDYINMTRDCASFIR
TRKYIVEPLTKEEVGFPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVD
RKAEESFLAAVQGIASCFDNVFVASQLESVVYASWTRVKADLNCMKDLYR
MNANWKYLINLSGMDFPIKTNLEIVRKLKCSTGENNLETEKMPPNKEERW
KKRYAVVDGKLTNTGIVKAPPPLKTPLFSGSAYFVVTREYVGYVLENENI
QKLMEWAQDTYSPDEFLWATIQRIPEVPGSFPSSNKYDLSDMNAIARFVK
WQYFEGDVSNGAPYPPCSGVHVRSVCVFGAGDLSWMLRQHHLFANKFDMD
VDPFAIQCLDEHLRRKALE
3D structure
PDB3otk Structural and mechanistic characterization of leukocyte-type core 2 beta 1,6-N-acetylglucosaminyltransferase: a metal-ion-independent GT-A glycosyltransferase.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.102: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N- acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A V128 H130 D155 V185 Y187 R192 S217 R378 K401 V73 H75 D100 V130 Y132 R137 S162 R323 K346
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0009101 glycoprotein biosynthetic process
GO:0016268 O-glycan processing, core 2
GO:0032868 response to insulin
GO:0048729 tissue morphogenesis
GO:0050901 leukocyte tethering or rolling
GO:0060352 cell adhesion molecule production
GO:0060993 kidney morphogenesis
GO:1903238 positive regulation of leukocyte tethering or rolling
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0031985 Golgi cisterna

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3otk, PDBe:3otk, PDBj:3otk
PDBsum3otk
PubMed22056345
UniProtQ09324|GCNT1_MOUSE Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Gene Name=Gcnt1)

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