Structure of PDB 3os1 Chain A

Receptor sequence

>3os1A (length=365) Species: 11963 (Human spumaretrovirus)

AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH

3D structure

• PDB: 3os1 The mechanism of retroviral integration from X-ray structures of its key intermediates
• Chain: A
• Resolution: 2.97 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	I112 L113 R114 P115 E207 F208 S209 T210 Q215 S216 K219 R222 D226 R229 S258 P259 K345 N348 R350 T351	I103 L104 R105 P106 E198 F199 S200 T201 Q206 S207 K210 R213 D217 R220 S249 P250 K336 N339 R341 T342
BS02	dna	A	P214 R222 S225 K228	P205 R213 S216 K219
BS03	dna	A	D128 G131 P132 D185 Q186 G187 Y212 R362	D119 G122 P123 D176 Q177 G178 Y203 R353
BS04	ZN	A	H62 H66 C96 C99	H53 H57 C87 C90
BS05	MG	A	D128 E221	D119 E212

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:3os1, PDBe:3os1, PDBj:3os1
• PDBsum: 3os1
• PubMed: 21068843
• UniProt: P14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)