Structure of PDB 3orq Chain A

Receptor sequence
>3orqA (length=373) Species: 426430 (Staphylococcus aureus subsp. aureus str. Newman) [Search protein sequence]
NAMNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRY
VAHEFIQAKYDDEKALNQLGQKCDVITYEFENISAQQLKLLCEKYNIPQG
YQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDIDKAIETLGYPFIVK
TRFGGYDGKGQVLINNEKDLQEGFKLIETSECVAEKYLNIKKEVSLTVTR
GNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNKIIQSIHFI
GTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQ
SLPNSIELLKPAVMMNLLGKDLDLLENEFNEHPEWHLHIYGKSERKDSRK
MGHMTVLTNDVNQTEQDMYAKFE
3D structure
PDB3orq Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus.
ChainA
Resolution2.23 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y154 E254 E267 N274 S275 K348
Catalytic site (residue number reindexed from 1) Y156 E256 E269 N276 S277 K350
Enzyme Commision number 6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E254 E267 E256 E269
BS02 ADP A R108 K148 Y154 D155 Q159 E183 Y185 L186 I188 E191 H214 F256 E267 R110 K150 Y156 D157 Q161 E185 Y187 L188 I190 E193 H216 F258 E269
BS03 POP A Y154 K340 R347 Y156 K342 R349
Gene Ontology
Molecular Function
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0034028 5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3orq, PDBe:3orq, PDBj:3orq
PDBsum3orq
PubMed21795812
UniProtA0A0H3KFM7

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