Structure of PDB 3orm Chain A

Receptor sequence
>3ormA (length=266) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
RYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRRE
AQNAAALNHPAIVAVYATGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP
MTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGI
ARAIATAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVS
VAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADL
VRVHNGEPPEAPKVLT
3D structure
PDB3orm Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 A142 N143 D156 T179
Catalytic site (residue number reindexed from 1) D129 K131 A133 N134 D147 T156
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A G18 G20 G21 M22 S23 V25 K40 V95 K140 M145 M155 D156 G9 G11 G12 M13 S14 V16 K31 V86 K131 M136 M146 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3orm, PDBe:3orm, PDBj:3orm
PDBsum3orm
PubMed21134645
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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