Structure of PDB 3orl Chain A

Receptor sequence
>3orlA (length=268) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
TPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSF
YLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD
IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAV
KVMDFGITAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSP
VSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRA
DLVRVHNGEPPEAPKVLT
3D structure
PDB3orl Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr kinase, PknB
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 A142 N143 D156 T179
Catalytic site (residue number reindexed from 1) D136 K138 A140 N141 D154 T158
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A L17 G20 G21 S23 V25 A38 K40 V95 R101 D102 K140 M145 L15 G18 G19 S21 V23 A36 K38 V93 R99 D100 K138 M143
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3orl, PDBe:3orl, PDBj:3orl
PDBsum3orl
PubMed
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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