Structure of PDB 3ork Chain A

Receptor sequence
>3orkA (length=274) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
SHMTTPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLAR
DPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGV
TLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISA
TNAVKVMDFGIATAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPF
TGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTA
AEMRADLVRVHNGEPPEAPKVLTD
3D structure
PDB3ork Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr kinase, PknB
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 A142 N143 D156 T179
Catalytic site (residue number reindexed from 1) D140 K142 A144 N145 D158 T163
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A F19 G20 G21 V25 K40 M92 V95 K140 A142 M145 M155 F21 G22 G23 V27 K42 M94 V97 K142 A144 M147 M157
BS02 MN A N143 D156 N145 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ork, PDBe:3ork, PDBj:3ork
PDBsum3ork
PubMed
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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