Structure of PDB 3orh Chain A

Receptor sequence
>3orhA (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
TPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAA
ASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQ
THKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHA
FRLLKPGGVLTYCNLTSWGELMKSKYSDITIMFEETQVPALLEAGFRREN
IRTEVMALVPPADCRYYAFPQMITPLVTKG
3D structure
PDB3orh The crystal structure of human guanidinoacetate N-methyltransferase with SAH
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.2: guanidinoacetate N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A W20 V41 M42 M50 G68 G70 M71 I73 A74 E90 C91 L116 W117 D135 T136 L139 W14 V35 M36 M44 G62 G64 M65 I67 A68 E84 C85 L110 W111 D129 T130 L133
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0030731 guanidinoacetate N-methyltransferase activity
Biological Process
GO:0006600 creatine metabolic process
GO:0006601 creatine biosynthetic process
GO:0006936 muscle contraction
GO:0007283 spermatogenesis
GO:0009887 animal organ morphogenesis
GO:0032259 methylation
GO:0040014 regulation of multicellular organism growth
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3orh, PDBe:3orh, PDBj:3orh
PDBsum3orh
PubMed
UniProtQ14353|GAMT_HUMAN Guanidinoacetate N-methyltransferase (Gene Name=GAMT)

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