Structure of PDB 3opr Chain A

Receptor sequence
>3oprA (length=258) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVV
LCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAA
AITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDHALPGDARDTTT
PASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIA
DKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGA
ALIEHWQR
3D structure
PDB3opr Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 K234 A237
Catalytic site (residue number reindexed from 1) S45 K48 S105 K202 A205
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MA4 A V224 P226 I246 A248 V261 A284 E288 V192 P194 I213 A215 V227 A250 E254
BS02 MA4 A R244 I279 R211 I245
BS03 SA2 A S70 Y105 S130 T235 G236 A237 S45 Y80 S105 T203 G204 A205 PDBbind-CN: -logKd/Ki=6.59,Ki=0.26uM
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:3opr, PDBe:3opr, PDBj:3opr
PDBsum3opr
PubMed21357298
UniProtP0AD64|BLA1_KLEPN Beta-lactamase SHV-1 (Gene Name=bla)

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