Structure of PDB 3opp Chain A

Receptor sequence
>3oppA (length=259) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVV
LCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAA
AITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDSWALPGDARDTT
TPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFI
ADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIG
AALIEHWQR
3D structure
PDB3opp Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 K234 A237
Catalytic site (residue number reindexed from 1) S45 K48 S105 K203 A206
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SA2 A S70 Y105 S130 N132 T235 G236 A237 S45 Y80 S105 N107 T204 G205 A206 PDBbind-CN: -logKd/Ki=6.28,Ki=0.53uM
BS02 MA4 A I221 V224 P226 A248 V261 A284 E288 I190 V193 P195 A216 V228 A251 E255
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:3opp, PDBe:3opp, PDBj:3opp
PDBsum3opp
PubMed21357298
UniProtP0AD64|BLA1_KLEPN Beta-lactamase SHV-1 (Gene Name=bla)

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