Structure of PDB 3op0 Chain A

Receptor sequence
>3op0A (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
RQWEEARALGRAVRMLQRLEEQCVDPRLSVSPPSLRDLLPRTAQLLREVA
HSRREAGGGGPGGPGGSGDFLLIYLANLEAKSRQVAALLPPRGRRSANDE
LFRAGSRLRRQLAKLAIIFSHMHAELHALFPGGKYCGHMYQLTKAPAHTF
WRESCGARCVLPWAEFESLLGTCHPVEPGCTALALRTTIDLTCSGHVSIF
EFDVFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQERLQACRDKPG
SYIFRPSCTRLGQWAIGYVSSDGSILQTIPANKPLSQVLLEGQKDGFYLY
PDGKTHNPDLTELGAENLYFQ
3D structure
PDB3op0 Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
ChainA
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S40 P41 Y244 R264 C267 T268 Y277 Q286 T287 I288 E300 F306 S31 P32 Y235 R255 C258 T259 Y268 Q277 T278 I279 E291 F297
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3op0, PDBe:3op0, PDBj:3op0
PDBsum3op0
PubMed
UniProtQ9ULV8|CBLC_HUMAN E3 ubiquitin-protein ligase CBL-C (Gene Name=CBLC)

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