Structure of PDB 3ooi Chain A

Receptor sequence
>3ooiA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
SKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKAT
DENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTL
QRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLT
LDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKA
GTELTFNYNLECLGNGKTVCKCGAPNCSGFLG
3D structure
PDB3ooi The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y120 Y207
Catalytic site (residue number reindexed from 1) Y121 Y208
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C172 C219 C221 C226 C173 C220 C222 C227
BS02 ZN A C44 C46 C54 C60 C45 C47 C55 C61
BS03 ZN A C54 C69 C74 C80 C55 C70 C75 C81
BS04 SAM A R101 W103 T143 N144 F145 Y146 R166 F167 N169 H170 Y207 N214 C219 K220 L230 R102 W104 T144 N145 F146 Y147 R167 F168 N170 H171 Y208 N215 C220 K221 L231
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3ooi, PDBe:3ooi, PDBj:3ooi
PDBsum3ooi
PubMed21196496
UniProtQ96L73|NSD1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-36 specific (Gene Name=NSD1)

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