Structure of PDB 3omp Chain A

Receptor sequence
>3ompA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWA
KKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLD
RDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPL
VTDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHA
SNKGMEHLLNMKCKNVVPVYDLLLEMLNA
3D structure
PDB3omp Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I310 K314 L324 V328 E332 E493 I47 K51 L61 V65 E69 E225
BS02 W14 A L301 A302 E305 L339 F356 L38 A39 E42 L76 F93 BindingDB: EC50=3800nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3omp, PDBe:3omp, PDBj:3omp
PDBsum3omp
PubMed21381753
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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