Structure of PDB 3ols Chain A

Receptor sequence
>3olsA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWA
KKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLD
RDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPL
VTDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHA
SNKGMEHLLNMKCKNVVPVYDLLLEMLNA
3D structure
PDB3ols Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K314 L324 V328 E332 E493 A497 K51 L61 V65 E69 E225 A229
BS02 EST A L298 E305 M336 F356 H475 L476 L35 E42 M73 F93 H207 L208 BindingDB: IC50=1.1nM,Kd=0.5nM,EC50=2.1nM,Ki=0.015nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3ols, PDBe:3ols, PDBj:3ols
PDBsum3ols
PubMed20922740
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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