Structure of PDB 3olr Chain A

Receptor sequence
>3olrA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
MASMDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTT
VAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPK
AYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPG
EMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHD
VPSSIDPILELIWDVRCYQEDDSVPICIHSSAGCGRTGVICAIDYTWMLL
KDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
3D structure
PDB3olr Structure basis of LYP substrate specificity revealed by reverse alanine screening and crystallography
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D195 S227 R233 T234 Q274
Catalytic site (residue number reindexed from 1) D198 S230 R236 T237 Q277
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R59 Y60 K61 D62 M134 S227 S228 A229 C231 G232 R233 Q274 R62 Y63 K64 D65 M137 S230 S231 A232 C234 G235 R236 Q277
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3olr, PDBe:3olr, PDBj:3olr
PDBsum3olr
PubMed
UniProtQ9Y2R2|PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (Gene Name=PTPN22)

[Back to BioLiP]