Structure of PDB 3ojy Chain A

Receptor sequence
>3ojyA (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]
ATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQ
ASCSSSTTCQAQCGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDV
RAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETVYNG
EWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNA
NDLLSKVKSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGML
QSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESL
GITSRDITTCFGGSLGIQYHCKKFGGGKTERARKAMAVEDIISRVRGGSR
STITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALD
QYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEAKADGSWSC
WSSWSVCRAGIQERRRECSCPGRKVQTQ
3D structure
PDB3ojy Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
ChainA
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A L83 N86 D88 D90 D96 E97 L80 N83 D85 D87 D93 E94
BS02 BMA A N13 W14 R29 N12 W13 R28
BS03 BMA A S511 W512 R530 S447 W448 R466
BS04 BMA A W515 R528 W451 R464
Gene Ontology
Molecular Function
GO:0001848 complement binding
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ojy, PDBe:3ojy, PDBj:3ojy
PDBsum3ojy
PubMed21454577
UniProtP07357|CO8A_HUMAN Complement component C8 alpha chain (Gene Name=C8A)

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