Structure of PDB 3oht Chain A

Receptor sequence
>3ohtA (length=331) Species: 8030 (Salmo salar) [Search protein sequence]
ERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVK
KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVY
LVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKP
SNLAVNEDCELKILDFGYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGR
TLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNF
ADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDPDDEPES
EPYDQSFESRQLEIEEWKRLTYEEVCSFETP
3D structure
PDB3oht p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D147 K149 N152 D165
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 A G32 V39 A52 K54 E72 L76 L105 T107 L109 M110 G111 N116 D169 F170 G28 V35 A48 K50 E68 L72 L101 T103 L105 M106 G107 N112 D165 F166
BS02 1N1 A D146 I147 I148 R150 W198 M199 N202 D142 I143 I144 R146 W177 M178 N181
BS03 1N1 A R190 I230 A256 Y259 R169 I209 A235 Y238
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0000165 MAPK cascade
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:3oht, PDBe:3oht, PDBj:3oht
PDBsum3oht
PubMed21699901
UniProtA9UJZ9

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