Structure of PDB 3ogq Chain A

Receptor sequence
>3ogqA (length=112) Species: 11673 (Feline immunodeficiency virus) [Search protein sequence]
GTTTTLEKRPEILIFVNGYPIKFLLDTGADITVLNRRDFQVKNSIENGRQ
MMIGIGGGKRGTNYINVHLEIRDENYKTQCIFGNVCVLEDNSLSVNLLGR
DNMIKFNIRLVM
3D structure
PDB3ogq Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AB1 A D30 G32 A33 D34 I35 I59 D26 G28 A29 D30 I31 I55 MOAD: ic50=30nM
PDBbind-CN: -logKd/Ki=7.52,IC50=30nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ogq, PDBe:3ogq, PDBj:3ogq
PDBsum3ogq
PubMed21636894
UniProtP16088|POL_FIVPE Pol polyprotein (Gene Name=pol)

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