Structure of PDB 3og7 Chain A

Receptor sequence
>3og7A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAF
KNEVGVLRKTRHVNILLFMGYSTAPQLAIVTQWCEGSSLYHHLHASFEMK
KLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGGSILW
MAPEVIRNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGS
LSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE
3D structure
PDB3og7 Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D125 K127 N129 N130 D143 S147
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 032 A I463 A481 L505 L514 T529 W531 C532 F583 D594 F595 G596 I15 A33 L57 L66 T81 W83 C84 F132 D143 F144 G145 PDBbind-CN: -logKd/Ki=7.51,IC50=31nM
BindingDB: IC50=31nM,Kd=51nM,EC50=2290nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3og7, PDBe:3og7, PDBj:3og7
PDBsum3og7
PubMed20823850
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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