Structure of PDB 3od0 Chain A

Receptor sequence
>3od0A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGK
DSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCT
RTATVKTLVNVKLWAIDRQCFQTIMMR
3D structure
PDB3od0 Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG A L172 F181 G182 E183 L184 A185 R192 T193 L81 F90 G91 E92 L93 A94 R101 T102 Manual survey: Kd=12+-1.6nM (21526164)
PDBbind-CN: -logKd/Ki=7.92,Kd=12nM
BS02 PCG A L187 N189 L96 N98 Manual survey: Kd=12+-1.6nM (21526164)
PDBbind-CN: -logKd/Ki=7.92,Kd=12nM
External links
PDB RCSB:3od0, PDBe:3od0, PDBj:3od0
PDBsum3od0
PubMed21526164
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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