Structure of PDB 3ocp Chain A

Receptor sequence
>3ocpA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGK
DSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCT
RTATVKTLVNVKLWAIDRQCFQTIMMR
3D structure
PDB3ocp Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A L172 F181 G182 E183 L184 A185 R192 T193 A194 L81 F90 G91 E92 L93 A94 R101 T102 A103 Manual survey: Kd=27+-3.6nM (21526164)
MOAD: Kd=27nM
PDBbind-CN: -logKd/Ki=7.57,Kd=27nM
External links
PDB RCSB:3ocp, PDBe:3ocp, PDBj:3ocp
PDBsum3ocp
PubMed21526164
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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