Structure of PDB 3obt Chain A

Receptor sequence
>3obtA (length=412) Species: 1491 (Clostridium botulinum) [Search protein sequence]
SAMASINDSKILSLQNKKNALVDTSGYNAEVRVGDNVQLNTIYTNDFKLS
SSGDKIIVNLNNNSAIYENSSVSFWIKISKDLTNSHNEYTIINSIEQNSG
WKLCIRNGNIEWILQDVNRKYKSLIFDYSESLSHTGYTNKWFFVTITNNI
MGYMKLYINGELKQSQKIEDLDEVKLDKTIVFGIDENIDENQMLWIRDFN
IFSKELSNEDINIVYEGQILRNVIKDYWGNPLKFDTEYYIINDNYIDRYI
APESNVLVLVQYPDRSKLYTGNPITIKSVSDKNPYSRILNGDNIILHMLY
NSRKYMIIRDTDTIYAECSQNCVYALKLQSNLGNYGIGIFSIKNIVKNKY
CSQIFSSFRENTMLLADIYKPWRFSFKNAYTPVAVTNYETKLLSTSSFWK
FISRDPGWVEPP
3D structure
PDB3obt Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K906 R967
Catalytic site (residue number reindexed from 1) K48 R106
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLB A D1171 T1172 D1173 K1192 R1239 D310 T311 D312 K327 R373
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:3obt, PDBe:3obt, PDBj:3obt
PDBsum3obt
PubMed20704566
UniProtP19321|BXD_CBDP Botulinum neurotoxin type D (Gene Name=botD)

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