Structure of PDB 3oad Chain A

Receptor sequence
>3oadA (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSR
LYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGIT
VTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVL
KEDVFSFYYNRD
3D structure
PDB3oad Design and optimization of new piperidines as renin inhibitors.
ChainA
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D38 S41 N43 W45 Y83
Catalytic site (residue number reindexed from 1) D35 S38 N40 W42 Y80
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LPO A T18 Q19 Y20 V36 D38 G40 W45 V46 H61 Y83 M114 F119 F124 D125 V127 T15 Q16 Y17 V33 D35 G37 W42 V43 H58 Y80 M111 F116 F121 D122 V124 MOAD: ic50=0.24nM
PDBbind-CN: -logKd/Ki=9.62,IC50=0.24nM
BindingDB: IC50=0.12nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3oad, PDBe:3oad, PDBj:3oad
PDBsum3oad
PubMed20843686
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

[Back to BioLiP]