Structure of PDB 3o8o Chain A

Receptor sequence
>3o8oA (length=750) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKY
LKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALV
VCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGS
IDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGW
LALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVA
EGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLAT
LQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIEN
KDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAP
SAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWH
NLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRD
GRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSA
SATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDIT
LLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRT
AIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVICVN
GSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVA
3D structure
PDB3o8o The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G215 R278 D309 S354 D356 D358 R400
Catalytic site (residue number reindexed from 1) G11 R74 D105 S150 D152 D154 R196
Enzyme Commision number 2.7.1.11: 6-phosphofructokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P A D356 M398 G399 R400 E455 H488 D152 M194 G195 R196 E251 H284
BS02 FDP A R665 V723 S724 Q767 G768 G769 E827 H859 R952 R461 V519 S520 Q563 G564 G565 E623 H655 R722
BS03 F6P A R391 K482 R187 K278
BS04 FDP A R760 R853 R556 R649
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3o8o, PDBe:3o8o, PDBj:3o8o
PDBsum3o8o
PubMed21241708
UniProtP16861|PFKA1_YEAST ATP-dependent 6-phosphofructokinase subunit alpha (Gene Name=PFK1)

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