Structure of PDB 3o6i Chain A

Receptor sequence
>3o6iA (length=263) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKL
KNKWWYDKGECGA
3D structure
PDB3o6i A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y61 T91 R96 G141 S142 T143 E193 Y61 T91 R96 G141 S142 T143 E193
BS02 O26 A I92 P105 M107 S108 S217 K218 G219 L239 S242 I92 P105 M107 S108 S217 K218 G219 L239 S242
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3o6i, PDBe:3o6i, PDBj:3o6i
PDBsum3o6i
PubMed20817521
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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