Structure of PDB 3o3g Chain A

Receptor sequence
>3o3gA (length=222) Species: 2336 (Thermotoga maritima) [Search protein sequence]
GIDELYKKEFGIVAGVDEAGRGCLAGPVVAAAVVLEKEIEGINDSKQLSP
AKRERLLDEIMEKAAVGIGIASPEEIDLYNIFNATKLAMNRALENLSVKP
SFVLVDGKGIELSVPGTCLVKGDQKSKLIGAASIVAKVFRDRLMSEFHRM
YPQFSFHKHKGYATKEHLNEIRKNGVLPIHRLSFEPVLELLTDDLLREFF
EKGLISENRFERILNLLGARKS
3D structure
PDB3o3g Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G23 N81 I82 F83 F185 E186 P187 G22 N80 I81 F82 F184 E185 P186
BS02 dna A G21 R22 G23 K47 D107 G108 V121 K122 K138 K159 H160 Y163 G20 R21 G22 K46 D106 G107 V120 K121 K137 K158 H159 Y162
BS03 CA A D18 E19 D17 E18
BS04 CA A D18 E19 D107 D17 E18 D106
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006298 mismatch repair
GO:0006401 RNA catabolic process
GO:0043137 DNA replication, removal of RNA primer
Cellular Component
GO:0005737 cytoplasm
GO:0032299 ribonuclease H2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3o3g, PDBe:3o3g, PDBj:3o3g
PDBsum3o3g
PubMed21095591
UniProtQ9X017|RNH2_THEMA Ribonuclease HII (Gene Name=rnhB)

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