Structure of PDB 3o29 Chain A

Receptor sequence
>3o29A (length=263) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKL
KNKWWYDKGECGA
3D structure
PDB3o29 A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y61 L90 T91 R96 L138 G141 S142 T143 E193 Y61 L90 T91 R96 L138 G141 S142 T143 E193
BS02 O29 A I92 P105 F106 M107 S108 S217 K218 G219 L239 S242 L247 D248 I92 P105 F106 M107 S108 S217 K218 G219 L239 S242 L247 D248
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3o29, PDBe:3o29, PDBj:3o29
PDBsum3o29
PubMed20805031
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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