Structure of PDB 3o1m Chain A

Receptor sequence
>3o1mA (length=201) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
PLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTN
CGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQ
PDACLINRYAPGAKLCLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRND
PLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAG
K
3D structure
PDB3o1m Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T51 P52 G53 Y55 M57 W69 Y76 K127 C129 H131 T38 P39 G40 Y42 M44 W56 Y63 K114 C116 H118
BS02 dna A R161 N162 R167 R148 N149 R154
BS03 MN A H131 D133 H187 H118 D120 H174
BS04 AKG A N120 Y122 L128 H131 H187 I189 R204 N206 R210 N107 Y109 L115 H118 H174 I176 R191 N193 R197
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0035515 oxidative RNA demethylase activity
GO:0035516 broad specificity oxidative DNA demethylase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair
GO:0035513 oxidative RNA demethylation
GO:0042245 RNA repair
GO:0070989 oxidative demethylation
GO:0072702 response to methyl methanesulfonate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3o1m, PDBe:3o1m, PDBj:3o1m
PDBsum3o1m
PubMed21068844
UniProtP05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB (Gene Name=alkB)

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