Structure of PDB 3nzi Chain A

Receptor sequence
>3nziA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
EDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIV
SEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQ
GKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGL
RNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDK
IKKFLTESHDR
3D structure
PDB3nzi Substrate-induced remodeling of the active site regulates human HTRA1 activity.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H220 L309 N324 Y325 G326 S328 T344 L345 K346 H61 L150 N165 Y166 G167 S169 T185 L186 K187
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3nzi, PDBe:3nzi, PDBj:3nzi
PDBsum3nzi
PubMed21297635
UniProtQ92743|HTRA1_HUMAN Serine protease HTRA1 (Gene Name=HTRA1)

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