Structure of PDB 3nz0 Chain A

Receptor sequence
>3nz0A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCG
PQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLR
DYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRNLAARNVLLDNDRLV
KIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSF
GVTLYELLTHCDSSQSPPTKFLELIGTVLRLTELLERGERLPRPDKCPCE
VYHLMKNCWETEASFRPTFENLIPILKTVHEKYRH
3D structure
PDB3nz0 A new regulatory switch in a JAK protein kinase.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 S1063
Catalytic site (residue number reindexed from 1) N136 A138 R140 N141 D154 S176
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IZA A L903 E905 G906 V911 A928 I960 M978 E979 Y980 V981 P982 G984 L1030 L16 E18 G19 V24 A41 I73 M91 E92 Y93 V94 P95 G97 L143 BindingDB: IC50=1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3nz0, PDBe:3nz0, PDBj:3nz0
PDBsum3nz0
PubMed21117080
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

[Back to BioLiP]