Structure of PDB 3nyx Chain A

Receptor sequence
>3nyxA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
PTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGEMVAVKALKADCGPQH
RSGWKQEIDILRTLYHEHIIKYKGCCEDQEKSLQLVMEYVPLGSLRDYLP
RHSIGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGD
FGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTL
YELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCP
CEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYRH
3D structure
PDB3nyx A new regulatory switch in a JAK protein kinase.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) N132 A134 R136 N137 D150 P173
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TZ1 A F908 K930 I960 Y962 L976 M978 V981 L1030 D1041 F1042 G1043 F20 K40 I70 Y72 L85 M87 V90 L139 D150 F151 G152 MOAD: Ki=32nM
PDBbind-CN: -logKd/Ki=7.49,Ki=32nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3nyx, PDBe:3nyx, PDBj:3nyx
PDBsum3nyx
PubMed21117080
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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