Structure of PDB 3nyn Chain A

Receptor sequence
>3nynA (length=553) Species: 9606 (Homo sapiens) [Search protein sequence]
ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLER
DYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKAC
GRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHE
YLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVC
ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY
AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED
LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY
MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQKKIKREEVERLVKEV
PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK
RLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFAT
GSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQR
LFS
3D structure
PDB3nyn Molecular basis for activation of G protein-coupled receptor kinases.
ChainA
Resolution2.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D311 K313 E315 N316 D329 E338 T348
Catalytic site (residue number reindexed from 1) D310 K312 E314 N315 D328 E337 T347
Enzyme Commision number 2.7.11.16: [G-protein-coupled receptor] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SGV A L192 V200 A213 M266 D270 L318 L191 V199 A212 M265 D269 L317 PDBbind-CN: -logKd/Ki=6.00,Kd=1uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0047696 beta-adrenergic receptor kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0009966 regulation of signal transduction
GO:0016055 Wnt signaling pathway
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3nyn, PDBe:3nyn, PDBj:3nyn
PDBsum3nyn
PubMed20729810
UniProtP43250|GRK6_HUMAN G protein-coupled receptor kinase 6 (Gene Name=GRK6)

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