Structure of PDB 3ny6 Chain A

Receptor sequence
>3ny6A (length=198) Species: 666 (Vibrio cholerae) [Search protein sequence]
HMAVITPQGVTNWTYQELEATHQALTREGYVFVGYHGTNHVAAQTIVNRI
APVNEEKWGGLYVATHAEVAHGYARIKEGTGEYGLPTRAERDARGVMLRV
YIPRASLERFYRTNTPLENAEEHITQVIGHSLPLRNEAFTGPESAGGEDE
TVIGWDMAIHAVAIPSTIPGNAYEELAIDEEAVAKEQSISTKPPYKER
3D structure
PDB3ny6 Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins.
ChainA
Resolution1.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E581
Catalytic site (residue number reindexed from 1) E150
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V30 A H460 G461 Y493 A501 Y504 E581 H36 G37 Y62 A70 Y73 E150
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3ny6, PDBe:3ny6, PDBj:3ny6
PDBsum3ny6
PubMed21135177
UniProtQ5EK40|CHXA_VIBCL Cholix toxin (Gene Name=chxA)

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