Structure of PDB 3ny3 Chain A

Receptor sequence
>3ny3A (length=70) Species: 9606 (Homo sapiens) [Search protein sequence]
LCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGG
FCDCGDTEAWKEGPYCQKHE
3D structure
PDB3ny3 Structural basis of substrate recognition and specificity in the N-end rule pathway.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T120 G146 G147 F148 D150 D153 T23 G49 G50 F51 D53 D56
BS02 ZN A C99 C124 C127 C149 C2 C27 C30 C52
BS03 ZN A C127 C151 C163 H166 C30 C54 C66 H69
BS04 ZN A C112 C115 H133 H136 C15 C18 H36 H39
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3ny3, PDBe:3ny3, PDBj:3ny3
PDBsum3ny3
PubMed20835242
UniProtQ8IWV8|UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 (Gene Name=UBR2)

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