Structure of PDB 3ns7 Chain A

Receptor sequence
>3ns7A (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
CSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVD
ITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM
SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQAC
RGDSPGVVWFKD
3D structure
PDB3ns7 Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) P42 R43 H102 G103 C150 R151
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3NS A R179 S236 H237 Q283 C285 R44 S101 H102 Q148 C150 PDBbind-CN: -logKd/Ki=8.33,Ki=4.68nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ns7, PDBe:3ns7, PDBj:3ns7
PDBsum3ns7
PubMed20656488
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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