Structure of PDB 3nr1 Chain A

Receptor sequence
>3nr1A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
GSEAAQLLEAADFAARKHRQQRRKDPEGTPYINHPIGVARILTHEAGITD
IVVLQAALLHDTVEDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERK
RLQVEQAPHSSPGAKLVKLADKLYNLRDLNRCTPEGWSEHRVQEYFEWAA
QVVKGLQGTNRQLEEALKHLFKQRGLTI
3D structure
PDB3nr1 A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H35 H61 D62 D122 H34 H60 D61 D121
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3nr1, PDBe:3nr1, PDBj:3nr1
PDBsum3nr1
PubMed20818390
UniProtQ8N4P3|MESH1_HUMAN Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Gene Name=HDDC3)

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