Structure of PDB 3npc Chain A

Receptor sequence
>3npcA (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
DNQFYSVEVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKK
LSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYL
VMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYAANV
DIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTV
RNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP
DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELI
YKEVMDW
3D structure
PDB3npc X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D145 K147 N150 D163 T182
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B96 A A53 K55 R69 E73 I86 L106 M108 L110 M111 D169 F170 A47 K49 R63 E67 I80 L100 M102 L104 M105 D163 F164 PDBbind-CN: -logKd/Ki=8.34,Kd=4.6nM
BindingDB: Kd=7.3nM,IC50=6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3npc, PDBe:3npc, PDBj:3npc
PDBsum3npc
PubMed20655210
UniProtP45984|MK09_HUMAN Mitogen-activated protein kinase 9 (Gene Name=MAPK9)

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