Structure of PDB 3nmq Chain A

Receptor sequence
>3nmqA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
GEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYE
SLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAK
SGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAW
ESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQ
FIGYPITLYLEKER
3D structure
PDB3nmq EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7PP A N51 A55 I96 G97 M98 L107 F138 W162 N39 A43 I84 G85 M86 L95 F126 W150 PDBbind-CN: -logKd/Ki=9.70,Ki=0.2nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:3nmq, PDBe:3nmq, PDBj:3nmq
PDBsum3nmq
PubMed21131419
UniProtP08238|HS90B_HUMAN Heat shock protein HSP 90-beta (Gene Name=HSP90AB1)

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