Structure of PDB 3nl0 Chain A

Receptor sequence

>3nl0A (length=475) Species: 12116 (Foot and mouth disease virus C)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDSRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGIPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALAH

3D structure

• PDB: 3nl0 A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	L108 D109 T115 A116 R128 K164 V181 R193 H204 G216 C217 N218 S298 G299 C300 S301 A302 T303 Y336	L108 D109 T115 A116 R128 K164 V181 R193 H204 G216 C217 N218 S298 G299 C300 S301 A302 T303 Y336
BS02	rna	A	K164 Y336 D338 D339 L386 K387 R388 I411 R416 T419 K423 S426 L430	K164 Y336 D338 D339 L386 K387 R388 I411 R416 T419 K423 S426 L430
BS03	MG	A	M111 R128	M111 R128

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:3nl0, PDBe:3nl0, PDBj:3nl0
• PDBsum: 3nl0
• PubMed: 20865120
• UniProt: Q9QCE4