Structure of PDB 3niz Chain A

Receptor sequence
>3nizA (length=288) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
YFQGLMEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRGIPSTAIREI
SLLKELHHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQ
IKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFG
IPVRHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGV
TDDDQLPKIFSILGTPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGF
CQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQI
3D structure
PDB3niz Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with ADP bound.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 Q148 N149 D162 T182
Catalytic site (residue number reindexed from 1) D124 K126 Q128 N129 D142 T159
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N149 D162 N129 D142
BS02 ADP A G32 V37 A49 K51 F100 M101 L151 D162 G18 V23 A35 K37 F80 M81 L131 D142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:3niz, PDBe:3niz, PDBj:3niz
PDBsum3niz
PubMed
UniProtQ5CRJ8

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