Structure of PDB 3nih Chain A

Receptor sequence
>3nihA (length=79) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VHKHTGRNCGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPKDHVNHHVCT
DICTEFTSGICDCGDEEAWNSPLHCKAEE
3D structure
PDB3nih Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T144 C145 V146 S172 G173 I174 D176 A182 T30 C31 V32 S58 G59 I60 D62 A68
BS02 ZN A C123 C148 C151 C175 C9 C34 C37 C61
BS03 ZN A H118 C151 C177 C189 H4 C37 C63 C75
BS04 ZN A C136 C139 H157 H160 C22 C25 H43 H46
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3nih, PDBe:3nih, PDBj:3nih
PDBsum3nih
PubMed20835240
UniProtP19812|UBR1_YEAST E3 ubiquitin-protein ligase UBR1 (Gene Name=UBR1)

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