Structure of PDB 3nif Chain A

Receptor sequence
>3nifA (length=454) Species: 9606 (Homo sapiens) [Search protein sequence]
LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEET
GGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW
SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNT
LSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNT
TEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGT
QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA
QPVV
3D structure
PDB3nif Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E243 D245 D247 T250 E252 E243 D245 D247 T250 E252
BS02 CA A D297 N299 D301 R303 D305 D297 N299 D301 R303 D305
BS03 CA A D365 D367 D369 Y371 D373 D365 D367 D369 Y371 D373
BS04 CA A D426 D428 N430 Y432 D434 D426 D428 N430 Y432 D434
BS05 NIF A F160 Y190 L192 D224 S225 F231 F160 Y190 L192 D224 S225 F231 PDBbind-CN: -logKd/Ki=5.10,IC50=8uM
BindingDB: IC50=9700nM
Gene Ontology
Cellular Component
GO:0008305 integrin complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3nif, PDBe:3nif, PDBj:3nif
PDBsum3nif
PubMed20679525
UniProtP08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)

[Back to BioLiP]