Structure of PDB 3ngo Chain A

Receptor sequence
>3ngoA (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
LPPRPWITLKERDILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEY
RKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRA
KIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNR
VMTKDNIGVAVVLEVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVS
EVKNILEKASIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELYNEC
LMNFSRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGV
LGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHP
3D structure
PDB3ngo Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y201 H360 W363 N412 F484 Y32 H180 W183 N220 F281
BS02 MG A D410 N412 H529 D218 N220 H326
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004535 poly(A)-specific ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3ngo, PDBe:3ngo, PDBj:3ngo
PDBsum3ngo
PubMed20628353
UniProtQ96LI5|CNO6L_HUMAN CCR4-NOT transcription complex subunit 6-like (Gene Name=CNOT6L)

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