Structure of PDB 3ngn Chain A

Receptor sequence
>3ngnA (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
LPPRPWITLKERDSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKK
GIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIM
SEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMT
KDNIGVAVVLEVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVK
NILEKASIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKERITHGFQL
KSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENN
ITGCPHPHIPSDHFSLLTQLELHP
3D structure
PDB3ngn Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A H360 W363 P365 K371 D410 N412 N479 F484 H529 H177 W180 P182 K188 D215 N217 N263 F268 H313
BS02 AMP A I271 M272 S273 E276 I99 M100 S101 E104
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004535 poly(A)-specific ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3ngn, PDBe:3ngn, PDBj:3ngn
PDBsum3ngn
PubMed20628353
UniProtQ96LI5|CNO6L_HUMAN CCR4-NOT transcription complex subunit 6-like (Gene Name=CNOT6L)

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