Structure of PDB 3ncu Chain A

Receptor sequence
>3ncuA (length=120) Species: 9606 (Homo sapiens) [Search protein sequence]
ENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQF
SSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQT
LYSKWKDFHFEKIPFDPAEM
3D structure
PDB3ncu Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A C829 H830 H847 F853 K858 K861 G874 I875 K888 K907 C26 H27 H44 F50 K55 K58 G71 I72 K85 K104 PDBbind-CN: Kd=29.2nM
BS02 rna A K849 F853 S854 K46 F50 S51 PDBbind-CN: Kd=29.2nM
BS03 ZN A C810 C813 C864 C869 C7 C10 C61 C66
External links
PDB RCSB:3ncu, PDBe:3ncu, PDBj:3ncu
PDBsum3ncu
PubMed20581823
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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