Structure of PDB 3nax Chain A

Receptor sequence
>3naxA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
KKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVP
YVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIG
SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG
TAKVLSPESKQARAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPF
RAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEG
YGPLKAHPFFESVTWENLHQQTPPKLTA
3D structure
PDB3nax Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 E209 N210 D223
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D148
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MP7 A G91 A109 K111 P125 Y126 M134 F142 V143 L159 Y161 A162 L196 L212 I221 T222 D223 F224 A227 G16 A34 K36 P50 Y51 M59 F67 V68 L84 Y86 A87 L121 L137 I146 T147 D148 F149 A152 BindingDB: EC50=1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3nax, PDBe:3nax, PDBj:3nax
PDBsum3nax
PubMed21118801
UniProtO15530|PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (Gene Name=PDPK1)

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