Structure of PDB 3n9o Chain A

Receptor sequence

>3n9oA (length=483) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]

PKESDRCGGCGKFTHEDKKNDFQWIGCDSCQTWYHFLCSGLEQFEYYLYE
KFFCPKCVPHTGHSIRYKVVAPHRYRWYSPNEKHLGIEVGSKTWIEDFIT
RENTVPSPTDDEVCIVEDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMT
MPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRP
LLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGAEYIKLLQR
EEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIA
APTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIH
AVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFE
LLHWMYMRNVLLEKITEANQEGSDMREQEKNIWTASQIMKAEMERWMDRE
LRLGPEILPTDDKNKIMISVRKQIEIQTKIQNA

3D structure

PDB

3n9o Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

Chain

Resolution

2.309 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	D196 F239 Q240 W241 I242 G243 C244 D245 Q248 W250 Y266	D5 F22 Q23 W24 I25 G26 C27 D28 Q31 W33 Y49
BS02	peptide	A	D389 I391 Q396 S397 T398 S424 V479 F482 F498 E531 S533 G580 N581 S607 K610 F611 Y612	D172 I174 Q179 S180 T181 S207 V262 F265 F281 E314 S316 G363 N364 S390 K393 F394 Y395
BS03	FE2	A	H495 D497 H567	H278 D280 H350
BS04	ZN	A	C198 C201 H252 C255	C7 C10 H35 C38
BS05	ZN	A	C244 C247 C271	C27 C30 C54

External links

PDB	RCSB:3n9o, PDBe:3n9o, PDBj:3n9o
PDBsum	3n9o
PubMed	20567261
UniProt	Q9GYI0\|KDM7_CAEEL Lysine-specific demethylase 7 homolog (Gene Name=jmjd-1.2)

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