Structure of PDB 3n8h Chain A

Receptor sequence
>3n8hA (length=262) Species: 177416 (Francisella tularensis subsp. tularensis SCHU S4) [Search protein sequence]
AMIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDV
VIVSIFVNPTQFNNPNDYQTYPNQLQQDIQILASLDVDVLFNPSEKDIYP
DGNLLRIEPKLEIANILEGKSRPGHFSGMLTVVLKLLQITKPNNLYLGEK
DYQQVMLIKQLVKDFFINTKIIVCPTQRQPSGLPLSSRNKNLTSTDIEIA
NKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFLAFYIGKVRL
IDNFLKETGPSC
3D structure
PDB3n8h Crystal Structure of Pantoate-beta-alanine Ligase from Francisella tularensis
ChainA
Resolution2.001 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M29 H33 H36 Q76 D77 I80 K149 S185 S186 R187
Catalytic site (residue number reindexed from 1) M30 H34 H37 Q77 D78 I81 K150 S186 S187 R188
Enzyme Commision number 6.3.2.1: pantoate--beta-alanine ligase (AMP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO A M29 Q60 R121 H124 D150 Q153 R187 M30 Q61 R122 H125 D151 Q154 R188
BS02 AMP A M29 H33 G35 H36 L39 L146 G147 K149 D150 T175 Q176 L184 M30 H34 G36 H37 L40 L147 G148 K150 D151 T176 Q177 L185
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004592 pantoate-beta-alanine ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0009058 biosynthetic process
GO:0015940 pantothenate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:3n8h, PDBe:3n8h, PDBj:3n8h
PDBsum3n8h
PubMed
UniProtQ5NF57|PANC_FRATT Pantothenate synthetase (Gene Name=panC)

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