Structure of PDB 3n8d Chain A

Receptor sequence
>3n8dA (length=329) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
TKENICIVFGGKSAEHEVSILTAQNVLNAIDKDKYHVDIIYITNDGDWRK
QNNITAEIKSTDELHLELEISQLLKESSSGQPYDAVFPLLNGEDGTIQGL
FEVLDVPYVGNGVLSAASSMDKLVMKQLFEHRGLPQLPYISFLRSEYEKY
EHNILKLVNDKLNYPVFVKPANLGSSVGISKCNNEAELKEGIKEAFQFDR
KLVIEQGVNAREIEVAVLGNDYPEATWPGEVVVQLKIPADLDEDVQLTLR
NMALEAFKETDCSGLVRADFFVTEDNQIYINETNAMPGFTAFSMYPKLWE
NMGLSYPELITKLIELAKERHQDKQKNKY
3D structure
PDB3n8d Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E16 V19 L22 S183 R291 D293 E306 N308 G312 F316
Catalytic site (residue number reindexed from 1) E15 V18 L21 S175 R267 D269 E282 N284 G288 F292
Enzyme Commision number 6.3.2.4: D-alanine--D-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A F175 K177 S183 I187 V216 E220 F295 N305 E306 F167 K169 S175 I179 V208 E212 F271 N281 E282
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008716 D-alanine-D-alanine ligase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3n8d, PDBe:3n8d, PDBj:3n8d
PDBsum3n8d
PubMed20729361
UniProtQ5HEB7|DDL_STAAC D-alanine--D-alanine ligase (Gene Name=ddl)

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